What is it about ApoE4 and the transport of cholesterol that increases Alzheimer’s risk?

Researchers are constantly looking into this question. There is a lot of research going into the underlying pathway for how ApoE4 relates to Alzheimer’s and it’s a worthy thing to investigate because of that strong association. The more we know about it, the more we can understand the pathways and then eventually, develop targets to intervene. ApoE4 is related to brain cell health—so, whether or not our brain cells have enough of the structure to be a solid cell; it relates to our synapses, which is the connection between cells, and that’s how our cells communicate. We know that ApoE deals with the maintenance and the health of those connections. There’s more and more evidence that ApoE is also related to vascular and blood vessel health between our brain cells and what feeds our brain health. The more we look into it, the more we see how related it is to so many different functions within the brain.