Brain Injury Study Sheds Light on Alzheimer’s Treatment

By | July 11th, 2017

It’s not abnormal to hear the phrase ‘traumatic brain injury’ and Alzheimer’s disease in the same sentence. That’s because a lot of research is focusing on how cognitive impairment brought on by injury can lead to dementia. Over half of people who’ve had an injury experience memory impairment and they’ve been shown to be twice as likely to get dementia. Other studies have shown that beta amyloid plaques, one of the hallmarks of Alzheimer’s start to build up rapidly in the brains of mice with brain injuries.

Scientists have found that injuries trigger an “integrated stress response,” in brain cells which disrupts their ability to synthesize the vital proteins they need to function and may make long-term memory formation difficult. They’ve been trying to come up with ways to boost memory and, in a recent study on mice, they succeeded. Researchers at the University of California, San Francisco, successfully used a memory-boosting compound to improve the deficits in mice following a brain injury.  They believe it holds promise for the development of new drugs, which, if successful, would be good news for Alzheimer’s patients.

Here’s where you can read more.

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2 thoughts on “Brain Injury Study Sheds Light on Alzheimer’s Treatment

  1. While I was in ICU following open heart surgery, I had a reaction to medication I was given, and started hallucinating. I got out of bed, and took a very bad fall, hitting my head. My memory was affected, but seemed to improve following my stay in rehab. A neurologist diagnosed me with mild cognitive disorder. He later did a bran scan, then changed the diagnosis to Alzheimer’s, and suggested my family immediately put me away in a care facility. He put me on medication (donzapel). I refused to be warehoused in a care facility. I live at home alone with my two dogs and two cats. I drive to a nearby market for food, etc., and am functioning well. I have an appt. with another neurologist in December. Any suggestions would be appreciated. I have difficulty sleeping due to the donzipel.

    1. I have had a large number of traumatic head injuries in childhood, adolescence, and adulthood due to accidents, mountain cycling, fist fights, boxing, playing American football, baseball injuries, hill walking and falls on streets and sidewalks. I was diagnosed with Alzheimer’s dementia in July 2023. Treatment since then with Donepezil has helped me, so far, over the last nine months.

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