An experimental form of brain stimulation using magnets is being studied for its benefits in Alzheimer's disease. Developing research suggests it could help treat autism, ADHD and OCD, too.
A brain stimulation technique called transcranial magnetic stimulation (TMS) is sparking the attention of neurologists around the globe. In the U.S., it’s already FDA approved for the treatment of neuropsychiatric conditions obsessive compulsive disorder and major depressive disorder, and in the past few years, it has turned heads for its yet unproven — but intriguing — early results in the treatment of Alzheimer’s.
A 2019 study out of Duke University found that the use of repetitive transcranial magnetic stimulation seemed to help improve working memory. That same year, researchers from the Northwestern University Feinberg School of Medicine in Chicago showed that another form of TMS — short-term, low-intensity transcranial alternating current stimulation — appeared to help boost long-term memory and working memory performance in older adults. Meanwhile, a systematic review of studies exploring the interplay between TMS and memory found the therapy did enhance episodic memory, with results lasting one to four months.
If TMS can move the dial in Alzheimer’s, what are its broader applications for diseases related to the brain?
Dr. Paul B. Fitzgerald, director of Australian National University’s School of Medicine and Psychology, works with TMS, and in his research, he’s exploring its broader applications to treat neuropsychiatric conditions, from depression to obsessive compulsive disorder. Here he dives into what transcranial magnetic stimulation is, how it works in the brain, and what it might accomplish.
Since the start of the COVID pandemic, there has been more attention given to problems of mental ill-health including depression than ever before. A new therapeutic option, especially for depression, transcranial magnetic stimulation, is slowly helping to address some of these considerable unmet needs in our community.
Research is also exploring the use of transcranial magnetic stimulation in many other conditions, including obsessive compulsive disorder, autism, attention deficit hyperactivity disorder, chronic pain and perhaps to slow the progression of dementia symptoms.
What do we know so far about this emerging form of treatment? And is it living up to its promise for people with depression?
How does TMS work, and who’s getting it now?
Transcranial magnetic stimulation involves the application of a series of magnetic pulses through a coil placed on the scalp. While the patient sits in a chair awake and relaxed, the magnetic field activates nerve cells in the brain, gradually changing the activity of brain circuits disrupted in depression. This is thought to help restore the normal interaction between brain regions.
Side effects are usually mild and temporary. They may include scalp discomfort, headache, tingling or facial twitching, and feeling lightheaded for a short time after a treatment session.
There is consistent evidence for the effectiveness of TMS treatment for acute episodes of depression. Its use is supported by many clinical trials as well as real-world studies showing benefits in more than 50 percent of patients receiving treatment. It attracted Medicare funding several years ago and is now being progressively rolled out around Australia.
The lasting effects and need for
maintenance doses of transcranial
magnetic stimulation need further study.
But there are several remaining problems with the use of TMS treatment. First, it involves a patient coming into the clinic daily, Monday to Friday, for four to six weeks. This is inefficient and costly.
Both these problems may ultimately be solved through the development of what are referred to as “accelerated” protocols – treatments that give higher doses on fewer days. A patient may have four or five days of high-dose treatment in one week rather than having all of the treatment dose spread out over a month or more.
Can TMS treat other conditions?
Alongside the clinical rollout of transcranial magnetic stimulation for depression, research is increasingly demonstrating its potential value in other conditions.
A series of studies have demonstrated that a somewhat different type of transcranial magnetic stimulation, which is able to stimulate deeper regions of the brain but which still comes from a scalp based coil, can be effective in the treatment of symptoms in some patients with obsessive compulsive disorder. This is a critical development as many patients with OCD fail to improve with medication and psychological treatments and there are few new therapies in development for the condition.
Transcranial magnetic stimulation for OCD has been approved for clinical use in the United States and is available in a limited number of clinical services in Australia.
The treatment is showing promise for addiction disorders, including the development of an approach using transcranial magnetic stimulation to help patients stop smoking. The initial trial of this approach showed at least a doubling of the percentage of patients who did not smoke over the first six weeks.
Transcranial magnetic stimulation may also help people manage chronic pain. Multiple approaches that use the technology show promise and guidelines are emerging, but a consistent clinical pathway has not yet been well defined.
A group of researchers across the country, led by Professor Peter Enticott in Melbourne, are conducting world-leading research trying to develop ways of using transcranial magnetic stimulation to help adolescent and adult patients with autism, especially to improve capacity for social understanding and interaction.
As clinical need escalates, early research is also exploring whether transcranial magnetic stimulation might alleviate symptoms of attention deficit hyperactivity disorder (ADHD).
Research has already demonstrated transcranial magnetic stimulation may improve, at least temporarily, thinking abilities in a range of disorders including Alzheimer’s disease. This is now being applied to see if it can improve attention for patients with ADHD. For now, this research remains in its infancy.
Do TMS’s effects last?
So far, the quality of the evidence on the persistence of effects and the need for maintenance treatment with the use of transcranial magnetic stimulation in depression is patchy. Research is looking at whether ongoing transcranial magnetic stimulation less often (for example one treatment every two weeks) may prevent the recurrence of depression in patients who have responded well. Preliminary studies suggest maintenance treatment is effective, but there there have been insufficient high-quality studies to convince Medicare to provide a subsidy for it.
Medicare funding also does not fund the provision of transcranial magnetic stimulation for patients who experience the return of their depression on more than one occasion. This is highly unusual. Patients with depression can have multiple courses of antidepressant medication, psychotherapy or electroconvulsive therapy based on similar levels of evidence. This is also true of most other medical therapies.
In clinical practice, and from the limited evidence available, it seems clear that if a patient has responded on one occasion to transcranial magnetic stimulation, they are likely to again. Until this is resolved, patients are in an unenviable situation. They know there is an effective treatment that has worked for them already, but they can only access it at considerable expense or via lengthy private hospital admission.