Are there different genes associated with different types of dementia?

Yes, there are. ApoE is specific to Alzheimer’s disease because of ApoE’s association with the amyloid protein. The amyloid protein is the one that is abnormal in the brain that eventually leads to further changes and what we would describe as Alzheimer’s. There are other genes related to Parkinson’s disease and Parkinson’s can cause dementia later on in life, as well as Lewy body dementia. Then there’s frontotemporal dementia, and there are some genetic associations. These are not as strong as ApoE is to Alzheimer’s, but these are still being actively investigated as well.