Would removing too much beta-amyloid plaque in the brain have any negative effects?

Not really. It’s a waste product that is constantly made and cleared. We see the brain scans of the people we treat and their brains are caked with amyloid, so we know that it’s potentially having a profound effect on their brain. The most promising results from drug trials have shown that when antibodies are effective at the highest doses that are used, they clear amyloid to the point where it converts somebody from amyloid positive to amyloid negative. So removing amyloid or preventing its occurrence in the first place is a major goal of the field.