What was found in the retina study?

In the one layer that uses the chemical transmitter in the cholinergic system the most, in the preclinical stages of the disease (before clinical onset of symptoms, possibly by a decade or more), there was evidence of increased volume of that structure which we think represents an inflammatory process. We know inflammation in the brain is a key key component in the pathophysiology of Alzheimer’s. We also found “inclusion bodies,” which we think are blotches of tissue that contain beta-amyloid protein aggregating right around that same layer and interfering with the transmission of light from the scanners.