Super Agers’ Increased Alzheimer’s Resistance

By Vipul Kamani | January 25th, 2021

Some older adults don't develop the key biomarkers of Alzheimer's, even in their 80s and 90s. Scientists try to crack the code about what protects their brains.

There are a lot of unanswered questions about Alzheimer’s, but one thing the Alzheimer’s community knows well is that getting older is the disease’s greatest known risk factor.  Generally, the buildup of beta-amyloid and tau tangles in the brain — key biomarkers of neurodegeneration —  increase as people age; abnormal levels of these proteins are linked to the onset of Alzheimer’s. 

However, a recent study correlated memory performance and brain scans of individuals 80 and older and found that some people are ‘super agers’ — individuals who performed remarkably well in memory tasks, even in advanced age. A brain scan of these cognitively sharp octogenarians revealed that they had a limited build-up of beta-amyloid plaques and tau tangles, akin to the brains of healthy younger people. 

“In our study, we observed that super agers do not appear to accumulate aging-associated proteins, such as tau and amyloid pathology,” lead researcher of the study and postdoctoral fellow at University Hospital Cologne in Germany, Merle Hoenig said in a news release. “In contrast, normal agers did present tau pathology, arguing that this ‘proteinopathy’ may be part of the normal aging process.”

The case of a Colombian woman, covered by the New York Times, can highlight one reason why some individuals are seemingly unaffected by this aging process. 

Aliria Rosa Piedrahita de Villegas, a resident of Colombia, carried the region-specific mutation in the PSEN1 gene, which causes early-onset Alzheimer’s. While it was expected that she would develop the disease in her 40s, she did not experience any symptoms until much later, at the age of 72. 

Researchers link this anomaly to the rare mutation of two genes — dubbed the Christchurch mutation, after Christchurch, New Zealand, where it was first observed — in her genetic profile. Ever since this finding, scientists are attempting to understand and replicate the protective effects of this mutation. 

What becomes clear, however, is that the genetic predisposition of a person may aid in their evasion of Alzheimer’s disease. Hoeing highlights how the new findings necessitate further exploration of the ‘molecular signature’ of people who are resistant to dementia-related conditions. 

While the preventive role of genes is being investigated, there are many things one can do to prevent or delay the onset of dementia. In a BrainTalk with Being Patient, Dr. Claudia Kawas,  professor of neurology, neurobiology, and behavior at the University of California, Irvine, outlined a few steps that everybody can take to reduce their risk from Alzheimer’s. 

“It could be [that genes play a role],” Kawas told Being Patient. “But it could also be an environmental resiliency.” According to a 2020 report published in The Lancet, getting exercise and eating a healthy diet are among the lifestyle factors that could reduce one’s likelihood of neurodegeneration late in life.

According to Kawas, another factor could be social interaction. During the current pandemic, social isolation has become a common phenomena. “[The effect of social engagement] is always minimized in our head,” Kawas said. “It doesn’t sound real scientific or it’s not a pill. But engaging with other people probably contributes more to brain health than we generally admit … It’s a very important kind of brain activity.”

If you find our articles and interviews helpful, please consider becoming a supporting member of our community. Frustrated by the lack of an editorially independent source of information on brain health and Alzheimer’s disease, we decided to create Being Patient. We are a team of dedicated journalists covering the latest research on Alzheimer’s, bringing you access to the experts and elevating the patient perspective on what it’s like to live with dementia.

Please help support our mission.

2 thoughts on “Super Agers’ Increased Alzheimer’s Resistance

  1. Great study! The colorful brain imaging visuals in the article serve as great vehicle, for providing reader with actual visualization of the scientific information explained, as pertains to Dimentia and Alzheimer’s Disease. Therefore, as written and presented, the information in this article certainly stands to promote greater awareness and understanding of the neuro disease subject matter investigated. Indeed, the focus placed on prevention of Dimentia and Alzheimer’s yields knowledge and hope for all in the world.

Leave a Reply

We are glad you have chosen to leave a comment. Please keep in mind that comments are moderated according to our comment policy.